CD4-Monoclonal Antibodies

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CD4

Qty


Total
$220
Catalog #
A1549
Antibody Type
Polyclonal Antibody
Gene ID
920
Swiss Prot
P01730
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW55kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human CD4
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymCD4mut
Images
  • A1549: image 1

    Western blot analysis of extracts of mouse thymus, using CD4 antibody.

Background

Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

Protocol

N/A

MSDS
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