CDKN1B-Polyclonal Antibodies

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CDKN1B

Qty


Total
$380
Catalog #
A0026
Antibody Type
Polyclonal Antibody
Gene ID
1027
Swiss Prot
P46527
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Rat
Tested applicationsWB IHC ICC IP FC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IP 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW27kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human CDKN1B
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationq
SynonymCDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1;
Images
  • A0026: image 1

    Western blot analysis of extracts of MCF-7 cell lysate, using CDKN1B antibody.

Background

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin 2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).

Protocol

N/A

MSDS
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