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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC IF |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Calculated MW | 18kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human CDKN2C |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | p18; INK4C; p18-INK4C; |
Western blot analysis of extracts of various cell lines, using CDKN2C antibody.
Immunohistochemistry of paraffin-embedded rat lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse stomach using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using CDKN2C antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using CDKN2C antibody.
Immunohistochemistry of paraffin-embedded rat brain using CDKN2C antibody.
Immunohistochemistry of paraffin-embedded mouse brain using CDKN2C antibody.
Immunofluorescence analysis of HeLa cell using CDKN2C antibody. Blue: DAPI for nuclear staining.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
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