CLDN8-Tag and Loading control Antibodies

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CLDN8

Qty


Total
$220
Catalog #
A8174
Antibody Type
Polyclonal Antibody
Gene ID
9073
Swiss Prot
P56748
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Rat
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW25kDa
Observed MWRefer to figures
ImmunogenRecombinant protein of human CLDN8
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Images
  • A8174: image 1

    Western blot analysis of extract of various cells, using CLDN8 antibody.

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

Protocol

N/A

MSDS
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