CREB1-Polyclonal Antibodies

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CREB1

Qty


Total
$480
Catalog #
A0011
Antibody Type
Polyclonal Antibody
Gene ID
1385
Swiss Prot
P16220
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat Monkey
Tested applicationsWB IHC IF IP FC
Recommended DilutionWB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW35kd
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human CREB1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationhikq
SynonymCREB ; CREB1; CREB 1
Images
  • A0011: image 1

    Western blot analysis of extracts of various cells, using CREB1 antibody.

Background

CREB1 is a bZIP transcription factor that activates target genes through cAMP response elements. CREB1 is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB1 is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB1 is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB1 signaling is involved in learning and memory in several organisms (4-6). CREB1 is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB1 is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB1 at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9).

Protocol

N/A

MSDS
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