|Reactivity||Human Mouse Rat Monkey|
|Tested applications||WB IHC IF IP FC|
|Recommended Dilution||WB 1:1000 - 1:4000
IHC 1:50 - 1:200
IF 1:50 - 1:100
IP 1:20 - 1:50
FC 1:20 - 1:50|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human CREB1|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||CREB ; CREB1; CREB 1|
CREB1 is a bZIP transcription factor that activates target genes through cAMP response elements. CREB1 is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB1 is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB1 is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB1 signaling is involved in learning and memory in several organisms (4-6). CREB1 is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB1 is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB1 at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9).
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