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Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IF IP |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:100 |
Calculated MW | 105kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human CTNND1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | t |
Synonym | CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120; |
Western blot analysis of extracts of various cell lines, using CTNND1 antibody.
Immunohistochemistry of paraffin-embedded Human gastric using CTNND1 antibody at dilution of 1:100 (x400 lens).
Immunohistochemistry of paraffin-embedded Human liver using CTNND1 antibody at dilution of 1:100 (x400 lens).
Immunohistochemistry of paraffin-embedded Human mammary cancer using CTNND1 antibody at dilution of 1:100 (x400 lens).
Immunohistochemistry of paraffin-embedded liver cancer using CTNND1 antibody at dilution of 1:100 (x400 lens).
Immunofluorescence analysis of U2OS cell using CTNND1 antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of HeLa cell using CTNND1 antibody. Blue: DAPI for nuclear staining.
Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4).Phosphorylation of Tyr904 on Catenin-δ-1 was identified at Cell Signaling Technology (CST) using PhosphoScan®, a CST's LC-MS/MS platform for phosphorylation site discovery (5).
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