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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC IF |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:100 |
| Calculated MW | 57kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human CYP2E1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | CPE1; CYP2E; P450-J; P450C2E; |
Western blot analysis of extracts of various cell lines, using CYP2E1 antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using CYP2E1 antibody at dilution of 1:100 (x400 lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using CYP2E1 antibody at dilution of 1:100 (x400 lens).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
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