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Reactivity | Human Mouse Rat |
Tested applications | WB IF |
Recommended Dilution | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Calculated MW | 32kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human Caspase3 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | CASP3;CPP32;CPP32B;SCA-1;Caspase-3;APOPAIN; |
Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins such as the nuclear enzyme poly(ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires aspartic acid at the P1 position (2).
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