DCX-Polyclonal Antibodies

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DCX

Qty


Total
$220
Catalog #
A0149
Antibody Type
Polyclonal Antibody
Gene ID
1641
Swiss Prot
O43602
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC
Recommended DilutionWB 1:200 - 1:2000 IHC 1:50 - 1:200
Calculated MW45kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human DCX
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationd
SynonymDC; DBCN; LISX; SCLH; XLIS;
Images
  • A0149: image 1

    Western blot analysis of extracts of Mouse brain, using DCX antibody.

Background

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Protocol

N/A

MSDS
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