DCX-Monoclonal Antibodies

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DCX

Qty


Total
$220
Catalog #
A1134
Antibody Type
Polyclonal Antibody
Gene ID
1641
Swiss Prot
O43602
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW45kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human DCX
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationd
SynonymDCX;DBCN;DC;LISX;SCLH;XLIS ;
Images
  • A1134: image 1

    Western blot analysis of brain cell lysate using DCX antibody.

Background

Mutations in Doublecortin cause Lissencephaly (smooth brain), a neuronal migration disorder characterized by epilepsy and mental retardation (1). Doublecortin is a microtubule associated protein that stabilizes and bundles microtubules. A conserved doublecortin domain mediates the interaction with microtubules, and interestingly most missense mutations cluster in this domain (2). Kinases JNK, CDK5 and PKA phosphorylate doublecortin. JNK phosphorylates Thr321, Thr331 and Ser334 while PKA phosphorylates Ser47 and CDK5 phosphorylates Ser297 (3-5). Phosphorylation of Ser297 lowers the affinity of doublecortin to microtubules. Furthermore, mutations of Ser297 result in migration defects (5).

Protocol

N/A

MSDS
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