|Tested applications||WB IHC|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:100 - 1:200|
|Observed MW||Refer to figures|
|Immunogen||Recombinant protein of human DDX39B|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||BAT1; UAP56; D6S81E;|
Western blot analysis of extracts of various cell lines, using DDX39B antibody.
Immunohistochemistry of paraffin-embedded human prostate cancer using DDX39B antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using DDX39B antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using DDX39B antibody at dilution of 1:100 (40x lens).
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
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