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Reactivity | Human Rat |
Tested applications | WB ICC IF |
Recommended Dilution | WB 1:500 - 1:2000 ICC 1:50 - 1:200 IF 1:50 - 1:100 |
Calculated MW | 120 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human DNMT3A |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | TBRS; DNMT3A2; M.HsaIIIA; |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
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