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Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IP FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IP 1:20 - 1:50 FC 1:20 - 1:50 |
Calculated MW | 42 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human DUSP6 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | HH19; MKP3; PYST1; |
Immunohistochemistry of paraffin-embedded mouse brain using DUSP6 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using DUSP6 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human pancreas using DUSP6 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse pancreas using DUSP6 antibody at dilution of 1:100 (40x lens).
Immunofluorescence
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
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