ECM1-Methylated Antibodies

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ECM1

Qty


Total
$220
Catalog #
A1513
Antibody Type
Polyclonal Antibody
Gene ID
1893
Swiss Prot
Q16610
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:1000 IHC 1:50 - 1:100
Calculated MW61kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human ECM1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymECM1; extracellular matrix protein 1; Secretory component p85;
Images
  • A1513: image 1

    Western blot analysis of extracts of various cell lines, using ECM1 antibody.

Background

ECM1 (extracellular matrix protein 1), also known as secretory component p85, is a secreted glycoprotein that is essential for the proper structure and function of the skin. It is widely expressed and localizes to the extracellular matrix. ECM1 binds to a variety of extracellular matrix components, including Perlecan, Fibulin and matrix metalloproteinase-9 (MMP-9), and participates in the structural organization of the dermis. In addition, ECM1 enhances the association of Collagen Type IV with Laminin 332 suggesting that it is a key player in interstitial dermis and the dermal-epidermal junction. Mutations in the gene encoding ECM1 result in the autosomal recessive disorder lipoid proteinosis (LiP). LiP is characterized by hyalinization of the dermis and reduplication of the basement membrane of the skin. LiP patients exhibit thickening of the skin and mucosae. Four splice variants (known as ECM1a-ECM1d) exist for ECM1.

Protocol

N/A

MSDS
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