|Tested applications||WB FC|
|Recommended Dilution||WB 1:500 - 1:2000
FC 1:20 - 1:50|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human EMD|
|Storage Buffer||Store at 4℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
EMD is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). EMD may regulate gene expression through binding to other transcriptional regulators (6,7). EMD binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that EMD is required for HIV-1 infectivity (9). Mutations in EMD are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).
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