EMD-Polyclonal Antibodies

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EMD

Qty


Total
$220
Catalog #
A0116
Antibody Type
Polyclonal Antibody
Gene ID
2010
Swiss Prot
P50402
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB FC
Recommended DilutionWB 1:500 - 1:2000 FC 1:20 - 1:50
Calculated MW29kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human EMD
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymEMD;EDMD;LEMD5;STA
Background

EMD is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). EMD may regulate gene expression through binding to other transcriptional regulators (6,7). EMD binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that EMD is required for HIV-1 infectivity (9). Mutations in EMD are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).

Protocol

N/A

MSDS
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