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Reactivity | Human Mouse Rat |
Tested applications | WB IHC ICC IF FC |
Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:200 FC 1:20 - 1:50 |
Calculated MW | 55 kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human ERG |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | p55; erg-3; |
Immunohistochemistry of paraffin-embedded mouse brain using ERG antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using ERG antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using ERG antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.
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