FLT3-Polyclonal Antibodies

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FLT3

Qty


Total
$220
Catalog #
A0081
Antibody Type
Polyclonal Antibody
Gene ID
2322
Swiss Prot
P36888
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC
Recommended DilutionWB 1:200 - 1:500 IHC 1:50 - 1:100
Calculated MW113kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human FLT3
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymFLT3;CD135;FLK2;STK1
Images
  • A0081: image 1

    Western blot analysis of extracts of mouse brain tissue using FLT3 antibody.

Background

FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1,2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia (7).

Protocol

N/A

MSDS
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