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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
Calculated MW | 61kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human GLUD1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | GDH; GDH1; GLUD; |
Western blot analysis of extracts of various cell lines, using GLUD1 antibody.
Immunohistochemistry of paraffin-embedded human colon using GLUD1 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using GLUD1 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using GLUD1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using GLUD1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using GLUD1 antibody at dilution of 1:100 (40x lens).
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
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