GSK3B-Monoclonal Antibodies

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GSK3B

Qty


Total
$300
Catalog #
A0480
Antibody Type
Monoclonal Antibody
Gene ID
2932
Swiss Prot
P49841
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW48kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human GSK3B
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbdimpqt
SynonymGSK3B; GSK-3β;
Images
  • A0480: image 1

    Western blot analysis of extracts of various cell lines, using GSK3B antibody.

Background

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).

Protocol

N/A

MSDS
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