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Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:100 |
Calculated MW | 55kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human HDAC1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | bfiptt |
Synonym | HD1; RPD3; GON-10; RPD3L1; |
Western blot analysis of extracts of various cell lines, using HDAC1 antibody.
Immunohistochemistry of paraffin-embedded human lung cancer using HDAC1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate cancer using HDAC1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using HDAC1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using HDAC1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of A549 cell using HDAC1 antibody. Blue: DAPI for nuclear staining.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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