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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Calculated MW | 14 kDa |
Observed MW | Refer to figures |
Immunogen | A specific peptide of Hydroxyl-Histone H2A-Y39 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | H2A.1; H2A.2; H2A/a; H2AFA; |
Immunohistochemistry of paraffin-embedded mouse colon using HIST1H2AE antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using HIST1H2AE antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using HIST1H2AE antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using HIST1H2AE antibody at dilution of 1:100 (40x lens).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
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