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Reactivity | Human Mouse Rat |
Tested applications | IHC ICC IF |
Recommended Dilution | IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:100 |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human INS |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10; |
Immunohistochemistry of paraffin-embedded mouse pancreas using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human pancreas using INS antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat pancreas using INS antibody at dilution of 1:100 (40x lens).
Immunofluorescence
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
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