ITGB1-Monoclonal Antibodies

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ITGB1

Qty


Total
$220
Catalog #
A0035
Antibody Type
Monoclonal Antibody
Gene ID
3688
Swiss Prot
P05556
Size
Species
Mouse
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:1000
Calculated MW130kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human ITGB1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymITGB1;CD29;FNRB;GPIIA;MDF2;MSK12;VLA-BETA;VLAB
Background

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).The β1 subfamily includes 12 distinct intergrin proteins that bind to different extracellular matrix molecules (4). Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the β1 cytoplasmic tail helps to regulate cell proliferation, cytoskeletal reorganization and gene expression (4). β1 integrin is implicated in various activities including embryonic development, blood vessel, skin, bone and muscle formation, as well as tumor metastasis and angiogenesis (4,5).

Protocol

N/A

MSDS
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