|Reactivity||Human Mouse Rat|
|Tested applications||WB IHC IF FC|
|Recommended Dilution||WB 1:500 - 1:1000
IHC 1:50 - 1:100
IF 1:20 - 1:50
FC 1:20 - 1:100|
|Observed MW||Refer to Figures|
|Immunogen||Recombinant protein of human KRT7|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||KRT7;CK7;K2C7;K7;MGC129731;MGC3625;SCL ;Cytokeratin 7|
Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers (1). Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).Keratin 7 and Keratin 19 are present in hepatic and pancreatic progenitor/stem cells (7,8).
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