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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
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| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC ICC IF IP FC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 FC 1:10 - 1:50 |
| Calculated MW | 85 kDa |
| Observed MW | Refer to figures |
| Immunogen | Recombinant protein of human LRP1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; |
Immunohistochemistry of paraffin-embedded mouse brain using LRP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using LRP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using LRP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse liver using LRP1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
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