LRP5-Polyclonal Antibodies

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LRP5

Qty


Total
$220
Catalog #
A0130
Antibody Type
Polyclonal Antibody
Gene ID
4041
Swiss Prot
O75197
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW179kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human LRP5
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymLRP5;BMND1;EVR1;EVR4;HBM;LR3;LRP7;OPPG;OPS;OPTA1;VBCH2;
Images
  • A0130: image 1

    Western blot analysis of extracts of various tissues, using LRP5 antibody.

  • A0130: image 2

    Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody at dilution of 1:200 (40x lens).

  • A0130: image 3

    Immunohistochemistry of paraffin-embedded human prostate using LRP5 antibody at dilution of 1:200 (40x lens).

  • A0130: image 4

    Immunohistochemistry of paraffin-embedded mouse lung using LRP5 antibody at dilution of 1:200 (40x lens).

Background

LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling (8-10).LRP5 is involved in the regulation of bone homeostasis. Mutations and polymorphisms in LPR5 are associated with bone diseases like osteoporosis-pseudoglioma syndrome and high-bone-mass disorders (11-13). In addition, mutations in LRP5 are found in patients with hyperparathyroid tumor and breast cancer (14,15).

Protocol

N/A

MSDS
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