MALT1-Monoclonal Antibodies

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MALT1

Qty


Total
$220
Catalog #
A2144
Antibody Type
Polyclonal Antibody
Gene ID
10892
Swiss Prot
Q9UDY8
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW92kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human MALT1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbl
SynonymDKFZp434L132; MLT; MLT1;
Images
  • A2144: image 1

    Western blot analysis of extracts of various cells, using MALT1 antibody.

  • A2144: image 2

    Immunofluorescence analysis of U20S cell using MALT1 antibody. Blue: DAPI for nuclear staining.

Background

Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-κB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-κB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-κB, contributing to increased oncogenic potential (7).

Protocol

N/A

MSDS
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