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Reactivity | Human Mouse |
Tested applications | WB |
Recommended Dilution | WB 1:200 - 1:2000 |
Calculated MW | 53kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human METAP2 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | p67; MAP2; MNPEP; p67eIF2; |
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
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