MLH3-Monoclonal Antibodies

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MLH3

Qty


Total
$220
Catalog #
A7796
Antibody Type
Polyclonal Antibody
Gene ID
27030
Swiss Prot
Q9UHC1
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW164kDa
Observed MWRefer to figures
ImmunogenRecombinant protein of human MLH3
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymHNPCC7;
Images
  • A7796: image 1

    Western blot analysis of extracts of various cells, using MLH3 antibody.

Background

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Protocol

N/A

MSDS
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