MLKL-Methylated Antibodies

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MLKL

Qty


Total
$380
Catalog #
A11458
Antibody Type
Monoclonal Antibody
Gene ID
197259
Swiss Prot
Q8NB16
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW54 kDa
Observed MWRefer to figures
ImmunogenRecombinant protein of human MLKL
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymhMLKL;
Images
  • A11458: image 1

    Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody at dilution of 1:100 (40x lens).

Background

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Protocol

N/A

MSDS
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