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Reactivity | Human Rat |
Tested applications | WB IHC ICC FC |
Recommended Dilution | WB 1:1000 - 1:2000 IHC 1:50 - 1:100 ICC 1:100 - 1:200 FC 1:500 - 1:1000 |
Calculated MW | 92/82/67kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human MMP9 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | MMP9;CLG4B;GELB;MANDP2;MMP-9; |
The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).
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