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| Reactivity | Human |
| Tested applications | WB IF FC |
| Recommended Dilution | WB 1:500 - 1:1000 IF 1:20 - 1:50 FC 1:20 - 1:50 |
| Calculated MW | 105kDa |
| Observed MW | Refer to Figures |
| Immunogen | A synthetic peptide of human MSH2 |
| Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | be |
| Synonym | MSH2;COCA1;FCC1;HNPCC;HNPCC1;LCFS2 |
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.
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