MSH2-Polyclonal Antibodies

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MSH2

Qty


Total
$220
Catalog #
A0064
Antibody Type
Polyclonal Antibody
Gene ID
4436
Swiss Prot
P43246
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IF FC
Recommended DilutionWB 1:500 - 1:1000 IF 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW105kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human MSH2
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbe
SynonymMSH2;COCA1;FCC1;HNPCC;HNPCC1;LCFS2
Images
  • A0064: image 1

    Western blot analysis of extracts of HeLa cell line, using MSH2 antibody.

Background

The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.

Protocol

N/A

MSDS
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