NCF1-Methylated Antibodies

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NCF1

Qty


Total
$220
Catalog #
A1148
Antibody Type
Polyclonal Antibody
Gene ID
653361
Swiss Prot
P14598
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW45kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human NCF1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymNCF1;FLJ79451;NCF1A;NOXO2;SH3PXD1A;p47phox ;
Images
  • A1148: image 1

    Western blot analysis of extracts of various cell lines, using NCF1 antibody.

Background

The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558 (1). Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease (2-4). Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure (5,6).

Protocol

N/A

MSDS
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