NCK1-Polyclonal Antibodies

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NCK1

Qty


Total
$220
Catalog #
A0140
Antibody Type
Polyclonal Antibody
Gene ID
4690
Swiss Prot
P16333
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200
Calculated MW43kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human NCK1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymNCK; nck-1; NCKalpha;
Images
  • A0140: image 1

    Western blot analysis of extracts of Mouse brain, using NCK1 antibody.

Background

NCK family adaptor proteins function to couple tyrosine phosphorylation signals to regulate actin cytoskeletal reorganization that leads to cell motility. Cytoplasmic protein NCK1 (or NCK alpha) is an adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 binds a number of intracellular proteins and influences various signaling pathways including GTPase-activating protein of Ras (RasGAP), which is responsible for the down-regulation of Ras. NCK1 is recently reported to regulate the UPR, which secondary to obesity impairs glucose homeostasis and insulin actions.

Protocol

N/A

MSDS
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