NCSTN-Polyclonal Antibodies

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NCSTN

Qty


Total
$220
Catalog #
A0128
Antibody Type
Polyclonal Antibody
Gene ID
23385
Swiss Prot
Q92542
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB
Recommended DilutionWB 1:500 - 1:2000
Calculated MW78kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human NCSTN
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationit
SynonymAPH2; RP11-517F10.1;
Images
  • A0128: image 1

    Western blot analysis of extracts of Mouse brain, using NCSTN antibody.

Background

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.

Protocol

N/A

MSDS
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