NFKBIA-Methylated Antibodies

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NFKBIA

Qty


Total
$220
Catalog #
A11397
Antibody Type
Polyclonal Antibody
Gene ID
4792
Swiss Prot
P25963
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IF
Recommended DilutionWB 1:500 - 1:2000 IF 1:20 - 1:100
Calculated MW39kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human NFKBIA
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymNFKBIA;IKBA;MAD-3;NFKBI ;
Images
  • A11397: image 1

    Western blot analysis of extracts of various cell lines, using NFKBIA antibody.

  • A11397: image 2

    Immunofluorescence analysis of HeLa cells using NFKBIA antibody.

Background

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).

Protocol

N/A

MSDS
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