NRG1-Polyclonal Antibodies

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NRG1

Qty


Total
$220
Catalog #
A0085
Antibody Type
Polyclonal Antibody
Gene ID
3084
Swiss Prot
Q02297
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC FC
Recommended DilutionWB 1:200 - 1:2000 IHC 1:50 - 1:200 FC 1:20 - 1:50
Calculated MW32kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human NRG1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymNRG1;ARIA;GGF;GGF2;HGL;HRG;HRG1;HRGA;NDF;SMDF;
Background

Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues (1,2). Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases.HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities (3).

Protocol

N/A

MSDS
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