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Reactivity | Human |
Tested applications | WB IHC FC |
Recommended Dilution | WB 1:200 - 1:2000 IHC 1:50 - 1:200 FC 1:20 - 1:50 |
Calculated MW | 32kDa |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human NRG1 |
Storage Buffer | Store at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | NRG1;ARIA;GGF;GGF2;HGL;HRG;HRG1;HRGA;NDF;SMDF; |
Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues (1,2). Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases.HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities (3).
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