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sales@neoscientific.com
+1-888.733.6849
+1-617.299.7367 (Int’l)
+1-888.733.6849
+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Calculated MW | 22kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human NTF4 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | NTF4;NT-4/5;NT4;NT5;NTF5 ; |
Western blot analysis of extracts of various cell lines, using NTF4 antibody.
Immunohistochemistry of paraffin-embedded human colon using NTF4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using NTF4 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver injury using NTF4 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat brain using NTF4 antibody at dilution of 1:100 (x40 lens).
NT-4 is a member of the structurally related neurotrophin family of proteins, which includes β-NGF, BDNF and NT-3 (1). NT-4 is expressed in a number of cell types and tissues, including neuronal cells, normal breast epithelial cells, melanocytes, activated T cells, and granulocytes (1-5). NT-4 is required for the development of peripheral sensory neurons (6,7). NT-4 may be important for the development of long term memory (8). Increased NT-4 expression in melanoma cells promotes cell proliferation and migration (5). NT-4 is secreted from cells as a precursor protein, which is proteolytically cleaved into the mature form (1). NT-4 signaling is mediated through two distinct receptors, the neurotrophin receptor p75NTR and the Trk tyrosine kinase receptor TrkB. While all neurotrophins bind to the p75NTR receptor, NT-4 preferentially binds to the TrkB receptor (1).
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