NTRK1-Polyclonal Antibodies

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NTRK1

Qty


Total
$380
Catalog #
A0072
Antibody Type
Polyclonal Antibody
Gene ID
4914
Swiss Prot
P04629
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC ICC IP FC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:100 ICC 1:50 - 1:100 IP 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW145kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human NTRK1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymMTC;TRK;TRK1;TRKA;Trk-A;p140-TrkA;High affinity nerve growth factor receptor antibody;gp140trk antibody;p140-TrkA antibody;
Images
  • A0072: image 1

    Western blot analysis of extracts of Rat brain cell line, using NTRK1 antibody.

Background

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF. Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC).

Protocol

N/A

MSDS
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