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Reactivity | Human Mouse Rat |
Tested applications | WB |
Recommended Dilution | WB 1:1000 - 1:2000 |
Calculated MW | 69kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human P2RX7 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | P2X7; |
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
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