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Reactivity | Human |
Tested applications | WB IHC FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 FC 1:20 - 1:50 |
Calculated MW | 32kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human PDCD1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; |
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
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