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Reactivity | Human Mouse Rat |
Tested applications | WB |
Recommended Dilution | WB 1:200 - 1:2000 |
Calculated MW | 96kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant Protein of human PDCD6IP |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | b |
Synonym | PDCD6IP; AIP1; Alix; DRIP4; HP95; MGC17003; |
Alix, a phylogenetically conserved cytosolic scaffold protein, contains an N-terminal Bro1 domain, a coiled-coil region and a C-terminal proline-rich domain (1,2). Originally identified as an ALG-2 (apoptosis-linked gene 2)-interacting protein involved in programmed cell death (3,4), Alix also regulates many other cellular processes, such as endocytic membrane trafficking and cell adhesion through interactions with ESCRT (endosomal sorting complex required for transport) proteins, endophilins, and CIN85 (Cbl-interacting protein of 85 kDa) (5,6).
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