PDIA3-Polyclonal Antibodies

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PDIA3

Qty


Total
$220
Catalog #
A0117
Antibody Type
Polyclonal Antibody
Gene ID
2923
Swiss Prot
P30101
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman
Tested applicationsWB IHC FC
Recommended DilutionWB 1:500 - 1:1000 IHC 1:50 - 1:100 FC 1:20 - 1:50
Calculated MW57kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human PDIA3
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbj
SynonymPDIA3;ER60;ERp57;ERp60;ERp61;GRP57;GRP58;HsT17083;P58;PI-PLC
Background

Secretory proteins translocate into the endoplasmic reticulum (ER) after their synthesis where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Disulfide isomerase (PDI) has two thioredoxin homology domains and catalyzes the formation and isomerization of these disulfide bonds (2). Other ER resident proteins that possess the thioredoxin homology domains, including endoplasmic reticulum stress protein 57 (PDIA3), constitute the PDI family (2). PDIA3 interacts with calnexin and calreticulin (3) and is suggested to play a role in the isomerization of disulfide bonds on certain glycoproteins (3).

Protocol

N/A

MSDS
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