PECAM1-Methylated Antibodies

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PECAM1

Qty


Total
$220
Catalog #
A11524
Antibody Type
Polyclonal Antibody
Gene ID
5175
Swiss Prot
P16284
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:100 - 1:200
Calculated MW83kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human PECAM1
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymPECAM1; CD31; FLJ58394; PECAM-1;
Images
  • A11524: image 1

    Western blot analysis of extracts of various cell lines, using PECAM1 antibody.

  • A11524: image 2

    Immunohistochemistry of paraffin-embedded human esophageal cancer using PECAM1 antibody at dilution of 1:100 (40x lens).

  • A11524: image 3

    Immunohistochemistry of paraffin-embedded human lung cancer using PECAM1 antibody at dilution of 1:100 (40x lens).

  • A11524: image 4

    Immunohistochemistry of paraffin-embedded human liver cancer using PECAM1 antibody at dilution of 1:100 (40x lens).

  • A11524: image 5

    Immunohistochemistry of paraffin-embedded human colon using PECAM1 antibody at dilution of 1:100 (40x lens).

Background

CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).

Protocol

N/A

MSDS
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