|Tested applications||WB IHC|
|Recommended Dilution||WB 1:500 - 1:2000
IHC 1:100 - 1:200|
|Observed MW||Refer to Figures|
|Immunogen||A synthetic peptide of human PECAM1|
|Storage Buffer||Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonym||PECAM1; CD31; FLJ58394; PECAM-1;|
Western blot analysis of extracts of various cell lines, using PECAM1 antibody.
Immunohistochemistry of paraffin-embedded human esophageal cancer using PECAM1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using PECAM1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using PECAM1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using PECAM1 antibody at dilution of 1:100 (40x lens).
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).
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