PHB-Polyclonal Antibodies

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PHB

Qty


Total
$220
Catalog #
A0056
Antibody Type
Polyclonal Antibody
Gene ID
5245
Swiss Prot
P35232
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IF
Recommended DilutionWB 1:500 - 1:2000 IF 1:50 - 1:200
Calculated MW30kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human PHB
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationbh
SynonymPHB;PHB1 ;
Images
  • A0056: image 1

    Western blot analysis of extracts of various cell lines, using PHB antibody.

  • A0056: image 2

    Immunofluorescence analysis of HeLa cell using PHB antibody. Blue: DAPI for nuclear staining.

Background

The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in multiple compartments in eukaryotic cells. PHB1 is 30kDa tumor suppressor protein involved in cell cycle control (1). PHB1 has been found in mitochondria, the nucleus and the plasma membrane, as well as extracellularly in circulation (2). In mitochondria prohibitins mainly exist as membrane-bound ring complexes and function as chaperones maintaining mitochondrial protein stability during protein synthesis and transportation (3,4). In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription (2,5). Extracellular prohibitin can bind and activate C3 to enhance complement activation (6).

Protocol

N/A

MSDS
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