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+1-888.733.6849
+1-617.299.7367 (Int’l)
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+1-617.299.7367 (Int’l)
| Reactivity | Human Mouse Rat |
| Tested applications | WB IHC |
| Recommended Dilution | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
| Calculated MW | 104kDa |
| Observed MW | Refer to Figures |
| Immunogen | Recombinant protein of human PKN1 |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA; |
Western blot analysis of extracts of various cells, using PKN1 antibody.
Immunohistochemistry of paraffin-embedded mouse brain using PKN1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human lung using PKN1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse lung using PKN1 antibody at dilution of 1:100 (x40 lens).
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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