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Reactivity | Human Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
Calculated MW | 57kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human PNKP |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | PNK; MCSZ; EIEE10; |
Western blot analysis of extracts of various cell lines, using PNKP antibody.
Immunohistochemistry of paraffin-embedded rat lung using PNKP antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cell using PNKP antibody. Green:GFP-RNF168 fusion protein expression for DNA damage marker.Blue: DAPI for nuclear staining. RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
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