PPP2R4-Monoclonal Antibodies

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PPP2R4

Qty


Total
$220
Catalog #
A1912
Antibody Type
Polyclonal Antibody
Gene ID
5524
Swiss Prot
Q15257
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB IHC IF
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Calculated MW40kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human PPP2R4
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationr
SynonymPP2A; PR53; PTPA;
Images
  • A1912: image 1

    Western blot analysis of extracts of MCF7 cell line, using PPP2R4 antibody.

  • A1912: image 2

    Immunohistochemistry of paraffin-embedded rat brain using PPP2R4 antibody at dilution of 1:200 (x400 lens)

  • A1912: image 3

    Immunohistochemistry of paraffin-embedded human kidney using PPP2R4 antibody at dilution of 1:200 (x400 lens)

  • A1912: image 4

    Immunofluorescence analysis of U2OS cell using PPP2R4 antibody. Blue: DAPI for nuclear staining.

Background

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Protocol

N/A

MSDS
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