PSEN1-Polyclonal Antibodies

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PSEN1

Qty


Total
$220
Catalog #
A0050
Antibody Type
Polyclonal Antibody
Gene ID
5663
Swiss Prot
P49768
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse
Tested applicationsWB IHC IF FC
Recommended DilutionWB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 FC 1:20 - 1:50
Calculated MW53kDa
Observed MWRefer to Figures
ImmunogenA synthetic peptide of human PSEN1
Storage BufferStore at 4℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentrationit
SynonymAD3; FAD; PS1; PS-1; S182;
Images
  • A0050: image 1

    Western blot analysis of extracts of 293 cell line, using PSEN1 antibody.

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Protocol

N/A

MSDS
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