PTK2-Monoclonal Antibodies

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PTK2

Qty


Total
$220
Catalog #
A11531
Antibody Type
Polyclonal Antibody
Gene ID
5747
Swiss Prot
Q05397
Size
Species
Rabbit
Isotype
IgG
Purity
Affinity purification
Additional Information
ReactivityHuman Mouse Rat
Tested applicationsWB
Recommended DilutionWB 1:1000 - 1:2000
Calculated MW119kDa
Observed MWRefer to Figures
ImmunogenRecombinant protein of human PTK2
Storage BufferStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SynonymFADK; FAK; FAK1; pp125FAK;
Images
  • A11531: image 1

    Western blot analysis of extracts of various cell lines, using PTK2 antibody.

Background

Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7).

Protocol

N/A

MSDS
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